Prolonged Mechanical Ventilation Induces Cell Cycle Arrest in Newborn Rat Lung
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Prolonged Mechanical Ventilation Induces Cell Cycle Arrest in Newborn Rat Lung
RATIONALE The molecular mechanism(s) by which mechanical ventilation disrupts alveolar development, a hallmark of bronchopulmonary dysplasia, is unknown. OBJECTIVE To determine the effect of 24 h of mechanical ventilation on lung cell cycle regulators, cell proliferation and alveolar formation in newborn rats. METHODS Seven-day old rats were ventilated with room air for 8, 12 and 24 h using...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0016910